Alagille Syndrome

Alagille syndrome is a genetic disorder that affects the liver, heart, kidney,
and other systems of the body. Problems associated with the disorder generally
become evident in infancy or early childhood. The disorder is inherited in an
autosomal dominant pattern, and the estimated odds of reciveing of Alagille syndrome is
1 in every 100,000 live births. It is named for Daniel Alagille. The severity of
the disorder can vary within the same family

The severity of the disorder can vary within the same family, with
symptoms ranging from so mild as to go unnoticed to severe heart and/or liver
disease requiring transplantation.


Signs and symptoms arising from liver damage in Alagille syndrome may include
a yellowish tinge in the skin and the whites of the eyes, itching, and deposits of cholesterol in the skin.